Brand Note
New insights into skin inflammation: Elucidating the effect of stress on skin inflammation
It is known that psychological stress causes various skin problems for busy modern people.
Previous research has also reported that stress weakens the skin’s barrier function and recovery ability, and it is known that a disruption in the skin barrier can cause a variety of symptoms such as dryness, rough skin, and itchiness.
Through the research of mind and skin, KOSÉ has now discovered that adrenaline, which is secreted in response to psychological stress, induces skin inflammation and reduces the function of tight junctions in the epidermis, which are important for the skin barrier.
What is a tight junction...?
The granular layer of the epidermis has a strong skin barrier structure that seals the gaps between adjacent cells without any gaps. If epidermal cells are compared to tiles, tight junctions serve as adhesion like the joints that fill the space between tiles. If a strong tight junction barrier is formed, it can prevent foreign substances from entering from the outside and moisture from evaporating from inside the skin.
Adrenaline-induced increase in inflammatory factors and structural changes in tight junctions
Inflammation-inducing effect of adrenaline
In an epidermal model where adrenaline was added, the structure of tight junctions changed
When adrenaline was added to a 3D epidermal model that experimentally reproduced human epidermis, it was found that the addition of adrenaline made the image of tight junctions unclear and caused disruption in the adhesion between cells.
To achieve healthy skin, it is important to prevent UV rays, dryness, and also inflammation and decline in barrier function caused by psychological stress.
The approach of SEKKISEI BLUE
Approach to skin inflammation
“Ginseng extract” derived from herbal medicine suppresses inflammatory factors caused by adrenaline
It has been confirmed that ginseng extract suppresses inflammation caused by adrenaline, making it effective for skin problems caused by psychological stress. Formulated as the main ingredient in SEKKISEI BLUE.
Ginseng extract
Fibroblast Activation, Anti-Inflammation, Moisturization
Ginseng extract is obtained from the root of the ginseng plant. It has long been used in Eastern herbal medicine as an herbal medicine effective in relieving fatigue, and promotes the proliferation of fibroblasts in the dermis, which in turn produce collagen and hyaluronic acid.
Ginseng extract suppresses inflammation of the stress hormone (adrenaline)
Approach to oxidation
'Grape Water' from the Southern Alps of Yamanashi Prefecture inhibits oxidation.
Inspired by the medicinal properties of grapes, such as replenishing moisture, eliminating waste, and enhancing bodily functions, this product contains grape leaf extract sourced from the Southern Alps of Yamanashi Prefecture. This extract has been confirmed to have strong antioxidant properties.
*Wiping toner and cream
Grape Water
Produced in Southern Alps of Yamanashi Prefecture
Antioxidant and moisturizing
This extract is derived from the leaves of the "Kaiji" variety, cultivated in the fertile soils of the Southern Alps in Yamanashi Prefecture. It contains tannins and flavonoids, which are known for their antioxidant effects.
*Variety may be subject to change without notice.
Antioxidant effect of grape leaf extract from the Southern Alps of Yamanashi Prefecture
